ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage
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چکیده
منابع مشابه
Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium
Acetaldehyde is an ethanol-derived definite carcinogen that causes oesophageal squamous cell carcinoma (ESCC). Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that eliminates acetaldehyde, and impairment of ALDH2 increases the risk of ESCC. ALDH2 is produced in various tissues including the liver, heart, and kidney, but the generation and functional roles of ALDH2 in the oesophagus remain elus...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2019
ISSN: 1476-5586
DOI: 10.1016/j.neo.2019.03.008